Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 Biomarker disease CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642 2004
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		0.400 Biomarker disease CTD_human Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. 23146691 2013
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.400 Therapeutic disease CTD_human Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK. 11820775 2002
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.400 Biomarker disease CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.400 Biomarker disease CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065 2005
Entrez Id: 1440
Gene Symbol: CSF3
CSF3 		0.400 Therapeutic disease CTD_human In those patients who survive the initial phase of poisoning, filgrastim (granulocyte colony-stimulating factor) offers an effective method of treating pancytopenia and preventing overwhelming septicemia. 17505274 2007
Entrez Id: 4843
Gene Symbol: NOS2
NOS2 		0.400 Biomarker disease CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957 2007
Entrez Id: 5624
Gene Symbol: PROC
PROC 		0.400 Therapeutic disease CTD_human Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). 17556722 2007
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.400 Biomarker disease CTD_human Innate immunity and inflammation in sepsis: mechanisms of suppressed host resistance in mice treated with ethanol in a binge-drinking model. 20624996 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 Biomarker disease CTD_human Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis. 8741040 1996
Entrez Id: 284
Gene Symbol: ANGPT1
ANGPT1 		0.400 Therapeutic disease CTD_human Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. 16005988 2005
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1 		0.400 Biomarker disease CTD_human Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. 19265175 2009
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.400 Therapeutic disease CTD_human Adenoviral delivery of human and viral IL-10 in murine sepsis. 11441115 2001
Entrez Id: 133
Gene Symbol: ADM
ADM 		0.400 Biomarker disease CTD_human Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis? 14766677 2004
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
Entrez Id: 4049
Gene Symbol: LTA
LTA 		0.390 Biomarker disease CTD_human Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. 22977509 2011
Entrez Id: 3929
Gene Symbol: LBP
LBP 		0.380 Biomarker disease CTD_human A functional variant of lipopolysaccharide binding protein predisposes to sepsis and organ dysfunction in patients with major trauma. 22167001 2012
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.350 Biomarker disease CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642 2004
Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI 		0.330 Biomarker disease CTD_human Anti-vascular inflammatory effects of pentacyclic triterpenoids from Astilbe rivularis in vitro and in vivo. 27887929 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.330 Biomarker disease CTD_human Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery. 20035746 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.330 Biomarker disease CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065 2005
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.330 Biomarker disease CTD_human Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats. 16003065 2005
Entrez Id: 4282
Gene Symbol: MIF
MIF 		0.320 Therapeutic disease CTD_human Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. 9892616 1999
Entrez Id: 3579
Gene Symbol: CXCR2
CXCR2 		0.320 Biomarker disease CTD_human Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide. 17138957 2007